Abstract #20: Amyloid beta 1-40 accumulation in rat brain tissues exposed to HIV-Protein Gp120 or 6-Hydroxydopamine

Kalil-Roldán, J., Román-Vega, R., Rivera-Crespo, Y., Colón, J., Alves, J., Inyushin, M. Department of Physiology, Universidad Central del Caribe, Bayamon, PR Department of Microbiology & Immunology, Universidad Central del Caribe, Bayamon, PR Amyloid beta accumulation is associated to the neurocognitive decline of patients with Parkinson’s Disease as well the collectively classified HIV-Associated Neurocognitive Disorders. Neuroinflammation […]

Abstract #19: APOE genotype affects chemotactic properties of APOE4 microglia in ex vivo brain slices

Jordy Sepulveda ¹, Michel Fallah³, Charlie Furlong¹, Stefano Vicini¹,³, and G. William Rebeck²,³. 1 Department of Pharmacology & Physiology, Georgetown University 2 Department of Neuroscience, Georgetown University 3 Interdisciplinary Program in Neuroscience, Georgetown University Background: Neuroinflammation exacerbates the progression of AD pathology. Neuroinflammation is modulated by APOE4, the strongest genetic risk factor for AD. In […]

Abstract #18: The effects of commercial melatonin in the associative memory of Caenorhabditis elegans as an Alzheimer’s model

Alissa M. Rodriguez Rodriguez, Joseline M. Velazquez Cintron and Zaira Mateo Mayol Alzheimer’s disease is a neurodegenerative disease characterized by the extracellular aggregation of β-amyloid plaques and tau protein entanglements. The accumulation of these β- amyloid plaques leads to progressive neural death, displaying as a decline in memory and cognitive function. Melatonin, a hormone produced […]

Abstract #17: Memantine and the 4R-cembranoid share similar nicotinic neuroprotective pathway in acute hippocampal slices

Antonio Henrique Martins¹, Yancy Ferrer-Acosta²,, Sergio Rodriguez-Massó¹, Dinely Pérez³, Vesna A. Eterovic⁴, P. A. Ferchmin⁴ 1 Department of Pharmacology and Toxicology, University of Puerto Rico; 2 Department of Neuroscience, Universidad Central del Caribe; 3 Department of Biochemistry, Universidad Central del Caribe; 4 Neuroprotection for Life Memantine was approved to treat patients with moderate to severe […]

Abstract #16: Closed-head injury increased avoidance in rats

Osmarie Martínez-Guzmán¹, Mauricio Cáceres-Chacón¹, Melissa Rivera-López¹, Héctor Haddock-Martínez ², and Demetrio Sierra-Mercado¹ 1 Department of Anatomy & Neurobiology, University of Puerto Rico (UPR) School of Medicine; 2 University of Puerto Rico, Río Piedras Campus (UPR-RP) The most common form of brain injury, concussion, is frequently seen in contact sports and military combat. Converging lines of […]

Abstract #14: Effects of Concussive-like Brain Injury on Fear Behaviors in Rats

G. Hernández-Busot, M. Rivera-López, O. Martínez-Guzmán, M. Cáceres-Chacón, D. Sierra-Mercado Department of Anatomy and Neurobiology, University of Puerto Rico School of Medicine, San Juan, P.R. 00936 Each year 40 million people worldwide suffer from traumatic brain injury, mainly in the form of concussions. Human studies have linked concussions with the development of fear-related disorders such […]

Abstract #13: Exploring

Rolando González Universidad Ana G. Mendez, Recinto Cupey Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world, with no known causes. Many studies have shown gene mutations and environmental toxins that may have a role in the onset of Parkinson’s disease. The creation of Lewy bodies, which promote the degeneration of […]

Abstract #12: Delivery of Edelfosine through the blood-brain barrier using a transferrin-based delivery system for epilepsy

Yancy Ferrer-Acosta¹*, Pedro A. Ferchmin², Yamixa Delgado-Reyes³* 1 Universidad Central del Caribe, Neuroscience Department, Bayamón, PR 2 Neuroprotection for Life Co., San Juan, PR 3 San Juan Bautista School of Medicine, Caguas, PR Memantine was approved to treat patients with moderate to severe Alzheimer’s disease. Memantine is an uncompetitive antagonist of moderate affinity to the […]

Abstract #11: The Involvement of the Renin-Angiotensin-System in the Generation of Phosphorylated Tau and Reactive Oxygen Species in Human Cortical Neuron Cell Lines

Luz De Dios ¹, Camille Collazo ², Yaritza Inostroza-Nieves¹ 1 Department of Biochemistry, San Juan Bautista School of Medicine, Caguas, Puerto Rico 2 Department of Biology, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico Alzheimer’s Disease (AD) is the most common cause of dementia. AD is a neurodegenerative disorder characterized by the […]