Abstract #33: Effects of chronic stress on cocaine seeking behavior after forced abstinence in male and female rats

Roberto J Morales-Silva, Ursula Gelpi-Domínguez, Joshua Perez-Torres, Yobet Perez-Perez, Genesis Rodriguez- Torres , Marian Sepulveda-Orengo Department of Basic Sciences, Ponce Health Sciences University-School of Medicine/Ponce Research Institute, Ponce, Puerto Rico 00732, USA Generally, Post-Traumatic Stress Disorder (PTSD) and Substance Use Disorder (SUD) are studied independently in preclinical studies, although they can occur concurrently in patients […]

Abstract #32: The effects of aerobic exercise on cocaine-induced cellular adaptations in the reward circuitry

Génesis Rodríguez-Torres¹, R. Morales-Silva¹, J. Pérez-Torres¹, Y. Pérez-Pérez¹, M. Martínez-Vélez² , H. Manso-Skerett ¹, U. Gelpí-Dominguez ¹, and M. Sepúlveda-Orengo¹ 1 Ponce Health Sciences University, Ponce Research Institute, Ponce, PR 2 Pennsylvania State University Cocaine is a psychostimulant drug that acts primarily on the limbic system. One of the main problems in cocaine addiction is […]

Abstract #31: BDNF expression in the mesolimbic reward system after extinction of opioid-seeking behavior in female rats

Wilma V. Richiez Mateo, Mario Lloret, Pedro Bonilla-Rullan, Roxsana Ayala-Pagán, Leslievette Hernández Román, and Jennifer L. Barreto Estrada, PhD Substance use disorders (SUD) are cognitive disorders of chronic relapse in which an organism develops a dependency to a substance. Although it is not fully understood, studies suggest that neuroplasticity changes on the neural circuits of […]

Abstract #30: Localization of Pedal Peptide 4-like Immunoreactivity in the Central Nervous System of Biomphalaria glabrata, an Intermediate Host for Intestinal Schistosomiasis

Frances Ramírez de Arellano Canetti, and Amanda Torres Arroyo The parasitic disease Schistosomiasis, also known commonly as bilharzia, is caused by the worm Schistosoma mansoni. It is currently the second most prevalent parasitic disease globally following malaria. It is estimated that more than 200 million people are infected worldwide. This parasite uses the snail Biomphalaria […]

Abstract #29: Discovery and development of anxiolytic agents from tropical marine macroalgae

Geraldine M. Ortiz-Sosa ², Nicole A. Colón-Rosa³ , Mikaela Rodríguez-González ¹, Gabriela M. Ramírez-Renta ¹, Aniel J. Rivera-Arzola ³, Ingrid N. De León-Ruíz ¹, Karen Díaz-García ¹ , Grayce E.Dyer Levin ⁴, Eduardo Caro-Díaz ⁴, Ricardo Chiesa ¹ 1 Department of Biology, 2 Natural Sciences General Program, 3 Department of Chemistry, University of Puerto Rico, […]

Abstract #28: A crosstalk between Transient Receptor Potential Vanilloid 1 and Cannabinoid Receptor 1 within limbic brain regions regulates depression-like behaviors triggered by stress in rats.

Wickensonn Norzé, Astrid Ramos, Amanda Rodriguez, Paola Eusebio,Valeria Schleier, Alexander Acevedo, Kristie Torres, Keimarie Berrios, Isabel Castellano, and Carmen S Maldonado-Vlaar. University of Puerto Rico Rio Piedras, Department of Biology, PO BOX 23360, San Juan, Puerto Rico. Clinical studies provide strong evidence that stress is an environmental risk factor that can trigger the onset of […]

Abstract #27: Metabolic Reprogramming of the Serine-Glycine-One-Carbon Biosynthetic Pathway as a possible target for neuroblastoma therapy

Fabiana Marini ¹,², Nicole Rodríguez ¹,², Roberto Angeli ¹,², Gerardo Caussade ¹,², Kiara Ayuso ¹,², Alejandra Vazquez ¹,² and Nataliya Chorna ¹,³ 1 PR-INBRE Metabolomics Research Core, University of Puerto Rico, School of Medicine, SJ, PR 2 Department of Biology, University of Puerto Rico, Rio Piedras Campus, SJ, PR 3 Department of Biochemistry, University of […]

Abstract #26: Effects of single prolonged stress on the rat medial prefrontal cortex proteome

Gustavo D. Hernández-Luciano¹, Y. Rivera-Escobales¹ , K. Carrasquillo-Carrión⁴, Y. M. Cantres-Rosario⁴, A. Rodríguez-De Jesús⁵, Y. Castillo-Ocampo¹ , C. Suarez-Gómez¹ , L. Sambolín-Escobales¹, M. Colón-Romero¹ , A. Roche-Lima⁴ , L. M. Meléndez-Aponte²,³,⁵, J. Porter¹ 1 Ponce Health Sciences University, Ponce Research Institute, Ponce, Puerto Rico 2 University of Puerto Rico Medical Sciences Campus 3 Department of […]

Abstract #25: Intermittent Cocaine Self-Administration but not Passive Cocaine Infusions Reduces H-Current in Putative Dopaminergic Neurons of the Ventral Tegmental Area

Omaris Vélez-Acevedo¹, Cristhian G. Calo-Guadalupe², Karl Y. Bosque-Cordero¹, Daisy Consuegra-García², Carlos A. Jiménez-Rivera² 1 Biology Department, University of Puerto Rico, Rio Piedras Campus 2 Physiology Department, University of Puerto Rico, Medical Sciences Campus Intermittent Access (IntA) cocaine self-administration is a protocol suggested to better simulate human drug use patterns due to its temporal dynamics of […]

Abstract #24: Evaluating the Role of Autism-associated Genes in Neuronal and Behavioral Plasticity

Andrea Edwards-Cintrón, Kristi Zoga & Michael P. Hart University of Puerto Rico, Río Piedras Campus Department of Genetics, Perelman School of Medicine, University of Pennsylvan Autism spectrum is a heterogeneous set of developmental conditions characterized by changes in behavior, including altered social skills, communication, and restricted and repetitive behaviors. Genetic studies have identified hundreds of […]